一般翻译成:incurable hopeless irretrievable beyond help等
例: What a hopeless fool I am!
我真是个无药可救的傻瓜!
an incurable pessimist
不可救药的悲观主义者
an incurable smoker
不可救药的烟民
He fell hopelessly in love with her.
他不可救药地爱上了她
incorrigible
incurable, incorrigible
It is from the classic movie 'Sound of Music'