用法一样，完全没有区别。what's wrong [释义] 怎么了; [例句]Hi, buddy. what's wrong with you?嘿，哥们儿，你怎么了？
你好，很高兴在这里回答你的问题！..what problem with是不正确的应该是What's the problem with
用于生病，用于问题
