It is in the application of our efforts that这里It is …that是一个强调句，第二个和第三个that都是定语从句的引导词，分别修饰先行词skills和our sense of selfesteem
it is...efforts that 为强调句，强调的是状语。其后的两个that引导的都是定语从句，先行词skills,self esteem 在从句中都做主语。
(It is) in the application of our efforts (that) we grow and master skills that enhance our sense of self esteem that contributes to our sense of happiness.
括号中成分构成强调结构
that enhance our sense of self esteem做定语修饰skill
that contributes to our sense of happiness.是self esteem的定语
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