解:如图,连接PA.∵在△ABC中,AB=6,AC=8,BC=10,∴BC2=AB2+AC2,∴∠A=90°.又∵PE⊥AB于E,PF⊥AC于F.∴∠AEP=∠AFP=90°,∴四边形PEAF是矩形.∴AP=EF.∴当PA最小时,EF也最小,即当AP⊥CB时,PA最小,∵ 1 2 AB?AC= 1 2 BC?AP,即AP= AB?AC BC = 6×8 10 =4.8,∴线段EF长的最小值为4.8;故选:B.