What's the matter with you?
What's wrong with you?
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What's wrong with you?/What happened to you?/What's the matter with you?
(望采纳!谢谢~~#^_^#)
what is the matter with you? 或 what is wrong with you?
What' s wrong with you?
What's the matter with you?
Are you in trouble?
How are you doing?
What‘s wrong with you?